研究生教育 > 导师介绍 > 博导 徐和平

博导 徐和平



徐和平教授,2013年起任英国贝尔法斯特女王大学终身教授, 眼免疫实验室主任, 生物服务部主任。2017年1月加入爱尔眼科研究所任副所长,眼病机理研究组首席研究员,中南大学爱尔眼科学院博士生导师。徐教授同时是湖南省“百人计划”入选者,湖南省科协“海智计划”与长沙市“引智计划”海外专家,“湖湘高层次人才聚集工程“创新人才。

徐教授师从世界著名的眼免疫学家John V. Forrester教授(英国皇家科学院院士,ARVO 2012 Weisenfeld Award获得者),自2005年建立独立实验室以来成绩卓著,其在英国贝尔法斯特女王大学所领导的团队被公认为是世界领先的眼免疫学研究团队之一。徐教授二十多年专注于眼科疾病的教学、临床与基础研究工作,特别是近年来在眼病机理以及治疗新方法的研究上建树颇丰。徐教授的研究涵盖了老年黄斑变性、糖尿病视网膜眼病和葡萄膜炎等眼科重要疑难病症。在老年黄斑变性发病机理研究方面率先提出了“亚炎症(para-inflammation)失调”致病的学说,改变了传统对老年型黄斑变性发病机理的认识,引起国际学界高度重视。除了眼病机理的基础研究工作,徐教授还致力于眼部新药开发的研究,共获得7个有关眼部药物开发的研究项目,部分已进入临床研究阶段。

他是英国最大的眼科基金会Fight for Sight、美国BrightFocus Foundation等研究基金会的评审委员会专家,中国国家自然科学基金委重点课题函评专家(2006-至今)和终审专家(2017),眼科药理与治疗协会(APOT)董事,同时担任Current Eye Research、Experimental Eye Research、Journal of Eye Science、Macrophage、Scientific Reports 等国际杂志编委。自2005年以来,徐教授以主持人身份获得了多项由欧盟、英国政府等资助的总计超450万英镑的科研基金,Blood、Prog Retin Eye ResGlia、EMBO Mol Med、Adv Drug Deliv Rev、Nature Protocols等杂志共发表了90多篇高质量的SCI论文,引用超过4200次,H因子39。参编9部眼科英文专著。受邀在国际大会、大学或研究机构做专题报告70多次,主持国际会议十余次。


近十年代表论文:

1. Little K, Ma JH, Yang N, Chen M, Xu H*. Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration – the potential sources and molecular cues for their recruitment and activation. EBioMedicine. 2018. https://doi.org/10.1016/j.ebiom.2018.11.029

2. Chen M, Chan CC, Xu H*. cholesterol homeostasis, macrophage malfunction and age-related macular degeneration. Ann Transl Med. 2018, doi: 10.21037/atm.2018.10.31

3. Chen M, Luo C, Zhao J, Devarajan G, Xu H*. Immune regulation in the aging retina. Prog Retin Eye Res. 2018 Oct 20. pii: S1350-9462(18)30044-2.

4. Akhtar-Schafer I, Wang L, Krohne T, Xu H, langmann T. Modulation of three key innate immune pathways for the most common retinal degenerative diseases. EMBO Mol Med. 2018 2018 Oct;10(10). pii: e8259. doi: 10.15252/emmm.201708259.

5. Cao L, Liu J, Pu J, Milne G, Chen M, Xu H, Shipley A, Forrester JV, McCaig CD, Lois N. Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology. J Cell Mol Med. 2018 Nov;22(11):5552-5564.  

6. Hombrebueno JR, Ali IHA, Ma JX, Chen M, Xu H. Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes. Diabetologia. 2018 Nov;61(11):2433-2446.  

7. Palvou S, Lindsay J, Ingram R, Xu H, Chen M. Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity. BMC Immunol. 2018,19(1),24.  

8. Amadio M, Kaarniranta K, Xu H, Smedowski A, Ferrington DA. Molecular Mechanisms Underlying Age-Related Ocular Diseases. Oxid Med Cell Longev. 2018 May 21;2018:8476164.

9. Luo C, Zhao J, Chen M, Xu H. The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye. Aging (Albany NY). 2018 Jun 13;10(6):1380-1389.

10. Kaarniranta K, Xu H, Kauppinen A. Mechanistical retinal drug targets and challenges. Adv Drug Deliv Rev. 2018 Feb 15;126:177-184.

11. Augustine J, Pavlou S, O'Hare M, Harkin K, Stitt A, Curtis T, Xu H, Chen M. Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1. Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1666-1674.

12. Chen M, Zhao J, Ali IHA, Marry S, Augustine J, Bhuckory M, Lynch A, Kissenpfennig A, Xu H. Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis. Am J Pathol. 2018 Apr;188(4):1007-1020.

13. Dinusha Rajapakse, Tim Curtis, Mei Chen, and Heping Xu. Zinc Protects Oxidative Stress-Induced RPE Death by Reducing Mitochondrial Damage and Preventing Lysosome Rupture. Oxid Med Cell Longev. 2017;2017:6926485.

14. Dinusha Rajapakse, Tim Curtis, Mei Chen, and Heping Xu. PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation. Aging (Albany NY). 2017 Oct 9;9(10):2052-2068.

15. Xu H and Chen M. Diabetic retinopathy and dysregulated innate immunity. Vision Res. 2017 Jun 2. 139:39-46.

16. Luckoff A, Scholz R, Sennlaub F, Xu H, Langmann T. Comprehensive analysis of mouse retinal mononuclear phagocytes. Nature Protocols. 2017. 12(6): 1136-1150.  

17. Lechner J, Chen M, Hogg RE, Toth L, Silvestri G, Chakravarthy U, Xu H. Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2(MCP-1) and CXCL8 (IL-8). J Neuroinflammation. 2017; 14:42.

18. Xu H, Chen M. Diabetic retinopathy and dysregulated innate immunity. Vis Res. 2017, 139:39-46. doi.org/10.1016/j.visres.2017.04.013.

19. De Cogan F, Hill LJ, Lynch A, Morgan-Warren PJ, Lechner J, Brerwick MR, Peacock AF, Chen M, Scott R, Xu H, Logan A. Topical delivery of anti-VEGF drugs to the ocular posterior segment using cell-penetrating peptides. Invest Ophthal Vis Sci. 2017,58(5):2578-2590.

20. De Majumdar S, Subinya M, Korward J, Pettigrew A, Scherer D, Xu H. A low concentration of tacrolimus/semifluorinated alkane (SFA) eyedrop suppresses intraocular inflammation in experimental mouse models of uveitis. Curr Mol Med. 2017,17(3):211-220.

21. Dong X, Wu W, ma L, Liu C, Bhuckory MB, Wang L, Nandrot EF, Xu H, Liu Y, Zhou W. Collectin-11 is an important modulator of retinal pigment epithelial cell phagocytosis and cytokine production. J Innate Immunity. 2017,9(6):529-545.

22. Chen, M., Rajapakse, D., Fraczek, M., Luo, C., Forrester, J. V. and Xu, H. Retinal pigment epithelial cell multinucleation in the aging eye – a mechanism to repair damage and maintain homoeostasis. Aging Cell. 2016. 15(3):436-445.  

23. Xu H and Chen M. Targeting the complement system for the management of retinal inflammatory and degenerative diseases. Eur J Pharmacol. 2016 March 3.  pii: S0014-2999(16)30112-1.  

24. Chen, M.; Lechner, J.; Zhao, J.; Toth, L.; Hogg, R.; Silvestri, G.; Kissenpfennig, A.; Chakravarthy, U.; Xu, H. STAT3 activation in circulating monocytes contributes to neovascular age-related macular degeneration. Curr Mol Med. 2016,16(4):412-423.

25. Lechner J, Chen M, Hogg RE, Toth L, Silvestri G, Chakravarthy U, Xu H. Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD. Immunity & Aging. 2016,13:4.  

26. Lechner J, Chen M, Hogg RE, Toth L, Silvestri G, Chakravarthy U, Xu H. Alterations in circulating immune cells in neovascular age-related macular degeneration. Sci Rep. 2015 Nov 17;5:16754.  

27. Chen M, Xu H. Parainflammation, chronic inflammation, and age-related macular degeneration. J Leukoc Biol. 2015 Nov;98(5):713-25.  

28. Zhao J, Chen M, Xu H. Experimental autoimmune uveoretinitis (EAU) related tissue damage and angiogenesis is reduced in CCL2-/-CX3CR1gfp/gfp mice. Invest Ophthalmol Vis Sci. 2014 Oct 23,55(11):7572-82

29. Hombrebueno JR, Chen M, Penalva RG, Xu H. Loss of synaptic connectivity in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse. PloS One. 2014 May 21; 9(5):e97970.

30. Luo C, Zhao J, Madden A, Chen M, Xu H. Complement expression in retinal pigment epithelial cells is modulated by activated macrophages. Exp Eye Res. 2013,112;93-101.

31. Chen M, Hombrebueno JR, Luo C, Penalva R, Zhao J, Colhoun L, Pandi S, Forrester JV, Xu H. Age- and light-dependent development of localized retinal atrophy in CCL2-/-CX3CR1GFP/GFP mice. PLoS ONE. 2013 Apr 18;8(4):e61381.

32. Chen M, Luo C, Penalva R, Xu H. Paraquat-induced retinal degeneration is exaggerated in CX3CR1 deficient mice and is associated with increased retinal inflammation. Invest Ophthalmol Vis Sci. 2013;54(1):682-690.

33. Luo C, Chen M, Madden A. Xu H. Expression of complement components and regulators by different subsets of bone marrow-derived macrophages. Inflammation. 2012; 35(4):1448-1461.

34. Forrester JV and Xu H. Good news – bad news: the Yin and Yang of immune privilege in the eye. Front Immun. 2012,3:338.

35. Chen M, Luo C, Zhao J, Pandi SP, Penalva R, Fitzgerald D, Xu H. Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole body irradiation is CCL2 dependent. Glia. 2012;60(5):833-842.

36. Chen M, Copland DA, Zhao J, Liu J, Forrester JV, Dick AD, Xu H. Persistent inflammation subverts thrombospondin-1 induced regulation of retinal angiogenesis, and is driven by CCR2 ligation. Am J Pathol. 2012;180(1):235-245.

37. Chen M, Forrester JV, Xu H. Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLoS ONE 2011;6(8):e22818.

38. Xu H, Chen M, Forrester JV, Lois N. Cataract surgery induces pro-inflammatory gene expression and protein secretion. Invest Ophthalmol Vis Sci. 2011. 52(1)249-255.  

39. Chen M, Muckerise E, Forrester JV, Xu H. Immune activation in retinal aging: a gene expression study. Invest Ophthalmol Vis Sci. 2010. 51(11):5888-5896.

40. Chen M, Muckersie E, Forrester JV, Xu H. Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis. Eur J Immunol. 2010. 40: 2870-2881

41. Xu H, Chen M, Forrester JV. (Review) Para-inflammation in the aging retina. Prog Retin Eye Res. 2009. 28(5):348-368.

42. Chen M, Muckersie E, Robertson M, Forrester JV, Xu H. Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina. Exp Eye Res. 2008, 87(6):543-440.

43. Xu H, Koch P, Chen M, Lau A, Reid DM, Forrester JV. A Clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp Eye Res. 2008, 87(4):319-326.

44. Chen M, Muckersie E, Roberston M, Fraczek M, Forrester JV, Xu H. Characterization of a mouse retinal pigment epithelial cell line: B6-RPE07. Invest Ophthalmol Vis Sci. 2008, 49(8):3699-3706.

45. Xu H, Manivannan A, Crane IJ, Dawson R, Liversidge J. Critical but divergent roles for CD62L and CD44 in directing monocyte trafficking in vivo during inflammation. Blood. 2008, 112(4):1166-74.

46. Xu H, Chen M, Manivannan A, Lois N, Forrester JV. Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell. 2008. 7; 58-68.

47. Xu H, Chen M, Mayer EJ, Forrester JV, Dick AD. Turnover of retinal microglia in adult experimental mouse. GLIA. 2007. 55; 1189-98.




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